Neuroendocrinology of amphibian metamorphosis.

Metamorphosis in Xenopus laevis is not associated with large-scale nuclear DNA content variation.

Amphibian metamorphosis is a complex process that has been speculated to involve DNA amplification and chromatin rearrangement. While recent studies have concentrated on chromatin rearrangement, only a few studies have dealt with variation in the amount of DNA during amphibian metamorphosis. In this study, nuclei were isolated from Xenopus laevis at various developmental stages. The nuclei were...

Programmed cell death during amphibian metamorphosis.

The death of different types of cells occurs in regressing or remodeling organs to transform from a tadpole to a frog in both temporally and spatially regulated manners during amphibian metamorphosis. This morphological change is drastic and visible with the naked eye. This review summarizes our current understanding of the basic mechanism of the cell death during the metamorphosis. It focuses ...

Are Commonly Used Fitness Predictors Accurate? A Meta-analysis of Amphibian Size and Age at Metamorphosis

A dominant-negative thyroid hormone receptor blocks amphibian metamorphosis by retaining corepressors at target genes.

The total dependence of amphibian metamorphosis on thyroid hormone (T(3)) provides a unique vertebrate model for studying the molecular mechanism of T(3) receptor (TR) function in vivo. In vitro transcription and developmental expression studies have led to a dual function model for TR in amphibian development, i.e., TRs act as transcriptional repressors in premetamorphic tadpoles and as activa...

Relation between Thyroid Gland, Metamor-

I t has been demonstrated by a number of workers that the active principle of the thyroid gland in the causation of amphibian metamorphosis is iodine. Recently Swingle 1 has obtained definite proof that inorganic iodine when fed to larvm of Salientia induces metamorphosis in a short time after the be#nning of the feeding. On the other hand, it has been shown by the writer 2 that the retarding i...